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2014


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Publications (2014)

3,3′,4′,5′-Tetrahydroxyflavone Induces Formation of Large Aggregates of Amyloid β Protein

Hiroko Ushikubo, Yui Tanimoto, Kazuho Abe, Tomohiro Asakawa, Toshiyuki Kan, Tatsuhiro Akaishi
Biol. Pharm. Bull., 37, 748–754 (2014). DOI: 10.1248/bpb.b13-00709

Structual specificity of electric potentials in the coulometric-array analysis of catechins and theaflavins

Kanako Matsuura, Yumiko Usui, Toshiyuki Kan, Takeshi ishii and Tsutomu Nakayama
J. Clin. Biochem. Nutr., 55, 103-109 (2014). DOI: 10.3164/jcbn.13-101

Total Syntheses of (+)-Sesamin and (+)-Sesaminol

Ryo Ishikawa, Naoto Yoshida, Yusuke Akao, Yusuke Kawabe, Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima, and Toshiyuki Kan
Chem. Lett., 43, 1572-1574 (2014). DOI: 10.1246/cl.140613

Editor's Choice (Open Access)

Practical synthesis of natural plant-growth regulator 2-azahypoxanthine, its derivatives, and biotin-labeled probes

Kazutada Ikeuchi, Ryosuke Fujii, Shimpei Sugiyama, Tomohiro Asakawa, Makoto Inai, Yoshitaka Hamashima, Jae-Hoon Choi, Tomohiro Suzuki, Hirokazu Kawagishi and Toshiyuki Kan
Org. Biomol. Chem., 12, 3813-3815 (2014). DOI: 10.1039/C4OB00705K

Neuroprotective effect of nobiletin on cerebral ischemia–reperfusion injury in transient middle cerebral artery-occluded rats

Nodoka Yasuda, Takayuki Ishii, Dai Oyama, Tatsuya Fukuta, Yurika Agato, Akihiko Sato, Kosuke Shimizu, Tomohiro Asai, Tomohiro Asakawa, Toshiyuki Kan, Shizuo Yamada, Yasushi Ohizumi, Naoto Oku
Brain Res., 1559, 46-54 (2014). DOI: 10.1016/j.brainres.2014.02.007

2-Azahypoxanthine and imidazole-4-carboxamide produced by the fairy-ring-forming fungus increases wheat yield

Hiroyuki Tobina, Jae-Hoon Choi, Tatsuo Asai, Yoshikazu Kiriiwa, Tomohiro Asakawa, Toshiyuki Kan, Akio Morita and Hirokazu Kawagishi
Field Crops Res., 162, 6-11(2014). DOI: 10.1016/j.fcr.2014.03.008

Practical Total Syntheses of Acromelic Acids A and B

Hitoshi Ouchi, Aya Asahina, Tomohiro Asakawa, Makoto Inai,
Yoshitaka Hamashima and Toshiyuki Kan
Org. Lett., 16 (7), 1980-1983 (2014). DOI: 10.1021/ol500529w

Stereocontrolled Total Synthesis of Hedyotol A

Yusuke Kawabe, Ryo Ishikawa, Yusuke Akao, Atsushi Yoshida, Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima and Toshiyuki Kan
Org. Lett., 16 (7), 1976-1979 (2014). DOI: 10.1021/ol500524y

Enantioselective Synthesis of SB-203207

Yasuo Hirooka, Kazutada Ikeuchi, Yuichiro Kawamoto, Yusuke Akao, Takumi Furuta, Tomohiro Asakawa, Makoto Inai, Toshiyuki Wakimoto, Tohru Fukuyama and Toshiyuki Kan
Org. Lett, 2014, 16 (7), 1646-1649 (2014). DOI: 10.1021/ol5002973

Use of positron emission tomography for real-time imaging of biodistribution of green tea catechin

Kosuke Shimizu, Tomohiro Asakawa, Norihiro Harada, Dai Fukumoto, Hideo Tsukada, Tomohiro Asai, Shizuo Yamada, Toshiyuki Kan, and Naoto Oku
PLOS ONE, 9, e85520 (2014). DOI: 10.1371/journal.pone.0085520

The Source of Fairy Rings: 2-Azahypoxanthine and its Metabolite Found in a Novel Purine Metabolic Pathway in Plants

Jae-Hoon Choi, Toshiyuki Ohnishi, Yasuhiro Yamakawa, Shogo Takeda, Shuhei Sekiguchi, Waki Maruyama, Kimiko Yamashita, Tomohiro Suzuki, Akio Morita, Takashi Ikka, Reiko Motohashi, Yoshikazu Kiriiwa, Hiroyuki Tobina, Tatsuo Asai, Shinji Tokuyama, Hirofumi Hirai, Nobuhiro Yasuda, Keiichi Noguchi, Tomohiro Asakawa, Shimpei Sugiyama,
Toshiyuki Kan, and Hirokazu Kawagishi
Angew. Chem. Int. Ed., 53, 1552 (2014). DOI: 10.1002/anie.201308109
This work was covered in Nature: A. Mitchinson, Nature, 505, 298. (2014). DOI: 10.1038/505298a

Practical Synthesis of Kainoids:A New Chemical Probe Precursor and a Fluorescent Probe

Shingo Sasaki, Hiroto Suzuki, Hitoshi Ouchi, Tomohiro Asakawa, Makoto Inai,
Ryuichi Sakai, Keiko Shimamoto, Yoshitaka Hamashima, and Toshiyuki Kan
Org. Lett., 16, 564-567 (2014). DOI: 10.1021/ol403434e

Synthetic Studies of Fisetin, Myricetin and Nobiletin Analogs and Related Probe Molecules

Aiki Hiza, Yuta Tsukaguchi, Takahiro Ogawa, Makoto Inai,
Tomohiro Asakawa, Yoshitaka Hamashima, and Toshiyuki Kan
HETEROCYCLES, Vol. 88, No. 2, 1371-1396 (2014). DOI: 10.3987/COM-13-S(S)107