グローバルナビゲーションへ

本文へ

ローカルナビゲーションへ

フッターへ



トップページ >  English >  CV >  Professor Toshiyuki KAN, Ph.D

Professor Toshiyuki KAN, Ph.D


このエントリーをはてなブックマークに追加

Toshiyuki Kan, Ph.D.
Professor


Personal Information:

Date of birth: February 15, 1964

Married: Maki Kan

Children: Natsuki Kan

School of Pharmaceutical Sciences University of Shizuoka University
52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan

Phone : 81-54-264-5746 FAX : 81-(0)-54-264-5745
e-mail : kant@u-shizuoka-ken.ac.jp
Home Page : https://www.us-yakuzo.jp/english/index.html

Education

B.S., Chemistry, March, 1986. Hokkido University, Sapporo, Hokkaido.
Under Professor Takeshi Matsumoto on "Synthetic Study of Thrsiferyl-23-acetate".
M.S., Chemistry, March, 1988. Hokkido University, Sapporo, Hokkaido.
Under Professor Haruhisa Shirahama on "Total Synthesis of Thrsiferyl-23-acetate".
Ph.D.,Chemistry, March, 1993. Hokkido University, Sapporo, Hokkaido.
Under Professor Haruhisa Shirahama on "Total Synthesis of Grayanotoxin III".

Honors and Awards

Incentive Award, The Society of Synthetic Organic Chemistry, Japan (2002)
Research Vision Division Award, 2003, Pharmaceutical Society of Japan (2004)
Pfizer Distinguished Lecture, Colorado State University (2012)
Asteras Life Science Award, The Society of Synthetic Organic Chemistry, Japan (2012)

Research and Professional Experience

Professor, University of Shizuoka, April 2004 ~ present.
Associate Professor, Tokyo University, November 2003 ~ March 2004.
Assistant Professor, Tokyo University, April 1996~October 2003.
Researcher, Suntory Institute for Bioorganic Research, June 1993 ~ March 1996.

Professional Society Memberships

American Chemical Society
Chemical Society of Japan
Society of Synthetic Organic Chemistry in Japan
Pharmaceutical Society of Japan

Publications

(147) Synthesis of 3-Amino-1,5-benzodiazepine-2-one Derivatives Using Dehydroalanine Derivatives
Nobuhiro Obara, Takeshi Watanabe, Tomohiro Asakawa, Toshiyuki Kan, Takao Tanaka
Synthesis 2019, in press.

(146) Practical synthesis of polymethylated flavone: nobiletin and its desmethyl derivatives
Tomohiro Asakawa, Hiroto Sagara, Masaki Kanakogi, Aiki Hiza, Yuta Tsukaguchi, Takahiro Ogawa, Miho Nakayama, Hitoshi Ouchi, Makoto Inai, Toshiyuki Kan
Org. Process Res. Dev., Article ASAP

(145) Consice Synthesis of TAN1251C
Yosuke Nagasaka, Sayaka Shintaku, Kosuke Matsumura, Akitaka Masuda, Tomohiro Asakawa, Makoto Inai, Masahiro Egi, Yoshitaka Hamashima, Yoshinobu Ishikawa, Toshiyuki Kan
Heterocycles 2019 in press

(144) Discovery of Plant Growth Stimulants by C−H Arylation of 2 Azahypoxanthine
Hiroyuki Kitano, Jae-Hoon Choi, Ayaka Ueda, Hideto Ito, Shinya Hagihara, Toshiyuki Kan, Hirokazu Kawagishi, Kenichiro Itami
Org. Lett., 20, 5684-5687 (2018)

(143) One-Pot Construction of 3-Phthalimido-1,5-benzodiazepine-2-one Derivatives via in situ Activation of N,N-Phthaloyl-serine
Nobuhiro Obara, Takeshi Watanabe, Tomohiro Asakawa, Toshiyuki Kan, Takao Tanaka
Synlett, 29, 1639-1643 (2018)

(142) Synthesis of double-13C-labeled imidazole derivatives
Hitoshi Ouchi, Tomohiro Asakawa, Kazutada Ikeuchi, Makoto Inai, Jae-Hoon Choi, Hirokazu Kawagishi, Toshiyuki Kan
Tetrahedron Lett., 59, 3516-3518 (2018)

(141) Binding of catechins to staphylococcal enterotoxin A
Shimamura Yuko, Utsumi Mio, Hirai Chikako, Nakano Shogo, Ito Sohei, Tsuji Ai, Ishii Takeshi, Hosoya Takahiro, Kan Toshiyuki, Ohashi Norio, Masuda Shuichi
Molecules 23, 1125 (2018)

(140) Concise synthesis of polymethoxyflavone sudachitin and its derivatives, and biological evaluations
Hiroto Sagara, Masaki Kanakogi, Yuki Tara, Hitoshi Ouchi, Junko Kimura, Yukiko Kaneko, Makoto Inai, Tomohiro Asakawa, Tomohisa Ishikawa, Toshiyuki Kan
Tetrahedron Lett., 59, 1816-1818 (2018)

(139) Total synthesis of natural products using a desymmetrization strategy
Makoto Inai, Tomohiro Asakawa, Toshiyuki Kan
Tetrahedron Lett., 59, 1343-1347 (2018)

(138) An efficient screening method for purifying and crystallizing membrane proteins using modified clear-native PAGE
Nanao Suzuki, Yuuki Takamuku, Tomohiro Asakawa, Makoto Inai, Tomoya Hino, So Iwata, Toshiyuki Kan, Takeshi Murata
Anal. Biochem., 548, 7-14 (2018)

(137) N-Glucosides of Fairy Chemicals, 2-Azahypoxanthine and 2-Aza-8-oxohypoxanthine, in Rice
Jae-Hoon Choi, Jing Wu, Azusa Sawada, Syougo Takeda, Hirohide Takemura, Kaoru Yogosawa, Hirofumi Hirai, Mitsuru Kondo, Kunihisa Sugimoto, Tomohiro Asakawa, Makoto Inai, Toshiyuki Kan, Hirokazu Kawagishi
Org. Lett., 20, 312-314 (2018)

(136) Rapid LC-MS Determination of Acromelic Acids A and B, Toxic Constituents of the Mushroom Paralepistopsis acromelalga
Naoki Yoshioka, Hitoshi Ouchi, Toshiyuki Kan, Masashi Yoshida, Motoyuki Nomura
Food Hygiene and Safety Science 58, 241-245 (2017)

(135) Total Synthesis of TAN1251C via Diastereoselective Construction of the Azaspiro Skeleton
Yosuke Nagasaka, Sayaka Shintaku, Kosuke Matsumura, Akitaka Masuda, Tomohiro Asakawa, Makoto Inai, Masahiro Egi, Yoshitaka Hamashima, Yoshinobu Ishikawa, Toshiyuki Kan
Org. Lett., 19, 3839-3842 (2017)

(134) Synthetic Study on Pactamycin: Stereoselective Synthesis of the Cyclopentane Core Framework
Atsumi Goto, Satoshi Yoshimura, Yuta Nakao, Makoto Inai, Tomohiro Asakawa, Masahiro Egi, Yoshitaka Hamashima, Mitsuru Kondo, Toshiyuki Kan
Org. Lett., 19, 3358-3361 (2017)

(133) Efficient synthesis of 3-amino-1,5-benzodiazepine-2-one derivatives
Nobuhiro Obara, Takeshi Watanabe, Tomohiro Asakawa, Toshiyuki Kan, Takao Tanaka
Synlett, 28, 1183-1186 (2017)

(132) Divergent synthesis of kinase inhibitor derivatives, leading to discovery of selective Gck inhibitors
Takanori Matsumaru, Makoto Inai, Kana Ishigami, Toshiki Iwamatsu, Hiroshi Maita, Satoko Otsuguro, Takao Nomura, Akira Matsuda, Satoshi Ichikawa, Masahiro Sakaitani, Satoshi Shuto, Katsumi Maenaka, Toshiyuki Kan
Bioorg. Med. Chem. Lett. 27, 2144-2147 (2017)

(131) Insulinotropic and anti-apoptotic effects of nobiletin in INS-1D ß-cells
Miki Takii, Yukiko K. Kaneko, Kiriko Akiyama, Yuki Aoyagi, Yuki Tara, Tomohiro Asakawa, Makoto Inai, Toshiyuki Kan, Kiyomitsu Nemoto, Tomohisa Ishikawa
J. Funct. Foods, 30, 8-15 (2017)

(130) Synthesis of chemical-biology tools enabling vivo imaging and analysis of epigallocatechin gallate
Tomohiro Asakawa, Atsushi Yoshida, Yasuo Hirooka, Takashi Suzuki, Kunihiko Itoh, Kosuke Shimizu, Naoto Oku, Takumi Furuta, Toshiyuki Wakimoto, Makoto Inai, Toshiyuki Kan
Heterocycles, 93, 218-242 (2016)

(129) Stereoselective Construction of 2-Vinyl 3-Hydroxybenzopyran Rings: Total Syntheses of Teadenols A and B
Ryunosuke Yoshida, Hitoshi Ouchi, Tomohiro Asakawa, Makoto Inai, Masahiro Egi, Yoshitaka Hamashima, Toshiyuki Kan
Org. Biomol. Chem., 14, 10783-10786 (2016)

(128) Concise synthesis of anserine: efficient solvent tuning in asymmetric hydrogenation reaction
Megumi Yamashita, Keita Shimizu, Yasuaki Koizumi, Toshiyuki Wakimoto, Yoshitaka Hamashima, Tomohiro Asakawa, Makoto Inai, Toshiyuki Kan
Synlett, 27, 2734-2736 (2016)

(127) Practical synthesis of spermine, thermospermine and norspermine
Yuka Kariya, Yuta Asanuma, Makoto Inai, Tomohiro Asakawa, Kyoko Ohashi-Ito, Hiroo Fukuda, Masahiro Egi, Toshiyuki Kan
Chem. Pharm. Bull., 64, 1403-1407 (2016)

(126) Applications of C-H Insertion Reaction in Total Synthesis of Biologically Active Heterocyclic Natural Products
Toshiyuki Kan, Tomohiro Asakawa, Makoto Inai
Heterocycles, 92, 31-43 (2016)

(125) Syntheses of methylated catechins and theaflavins using 2-nitrobenzenesulfonyl group to protect and deactivate phenol
Tomohiro Asakawa, Yusuke Kawabe, Atsushi Yoshida, Yoshiyuki Aihara, Tamiko Manabe, Yoshitsugu Hirose, Asuka Sakurada, Makoto Inai, Yoshitaka Hamashima, Takumi Furuta, Toshiyuki Wakimoto, Toshiyuki Kan
J. Antibiot., 69, 299-312 (2016)

(124) Synthesis of food effective constituents toward the development for chemical biology investigations
Makoto Inai, Tomohiro Asakawa, Toshiyuki Kan
J. Syn. Org. Chem., Jpn, 74, 412-425 (2016)

(123) Practical Total Syntheses of Acromelic Acids A and B
Makoto Inai, Hitoshi Ouchi, Aya Asahina, Tomohiro Asakawa, Yoshitaka Hamashima, Toshiyuki Kan
Chem. Pharm. Bull., 64, 723-732 (2016)

(122) Nobiletin: a citrus flavonoid displaying potent physiological activity
Shuji Noguchi, Haruka Atsumi, Yasunori Iwao, Toshiyuki Kan, Shigeru Itai
Acta Cryst., C72, 124-127, (2016)

(121) A negative feedback loop controlling bHLH complexes is involved in vascular cell division and differentiation in the root apical meristem
Hirofumi Katayama, Kuninori Iwamoto, Yuka Kariya, Tomohiro Asakawa, Toshiyuki Kan, Hiroo Fukuda, Kyoko Ohashi-Ito
Curr. Biol., 25, 3144-3150 (2015)

(120) Stereocontrolled Total Syntheses of Optically Active Furofuran Lignans
Inai, M.; Ishikawa, R.; Yoshida, N.; Shirakawa, N.; Akao, Y.; Kawabe, Y.; Asakawa, T.; Egi, M.; Hamashima, Y.; Kan, T.
Synthesis 47, 3513-3521 (2015)

(119) Ecteinascidins. A review of the chemistry, biology and clinical utility of potent tetrahydroisoquinoline antitumor antibiotics
V. H. Le, M. Inai, R. M. Williams, T. Kan
Nat. Prod. Rep. 32, 328-347 (2015)

(118) The “fairy” (2-azahypoxanthine) produced by the fairy-ring-forming fungus promotes the growth and the grain yield of rice
Asai, T., Choi, J-H., Ikka, T., Fushimi, K., Abe, N., Tanaka, H., Yamakawa, Y., Kobori, H., Kiriiwa, Y., Motohashi, R., Deo, V. P., Asakawa, T., Kan, T., Morita, A., Kawagishi, H.
Jpn. Agric. Res. Quart 49, 45-49 (2015)

(117) Total Syntheses of (+)-Sesamin and (+)-Sesaminol
Ryo Ishikawa, Naoto Yoshida, Yusuke Akao, Yusuke Kawabe, Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima, Toshiyuki Kan
Chem. Lett., 43, 1572-1574 (2014) Editor’s Choice

(116) Structual specificity of electric potentials in the coulometric-array analysis of catechins and theaflavins
Kanako Matsuura, Yumiko Usui, Toshiyuki Kan, Takeshi ishii, Tsutomu Nakayama
J. Clin. Biochem. Nutr., 55, 103-109 (2014)

(115) 3,3',4',5'-tetrahydroxyflavone induces formation of large aggregates of amyloid β protein
H. Ushikubo, Y. Tanimoto, K. Abe, T. Asakawa, T. Kan, T. Akaishi
Biol. Pharm. Bull., 37, 748–754 (2014)

(114) Practical synthesis of natural plant-growth regulator 2-azahypoxanthine, its derivatives, and biotin-labeled probes
Kazutada Ikeuchi, Ryosuke Fujii, Shimpei Sugiyama, Tomohiro Asakawa, Makoto Inai, Yoshitaka Hamashima, Jae-Hoon Choi, Tomohiro Suzuki, Hirokazu Kawagishi, Toshiyuki Kan
Org. Biomol. Chem., 12, 3813-3815 (2014)

(113) Synthesis of biological active natural products by means of C-H insertion reaction
Toshiyuki Kan
J. Syn. Org. Chem., Jpn, 72, 171 (2014)

(112) Neuroprotective effect of nobiletin on cerebral ischemia–reperfusion injury in transient middle cerebral artery-occluded rats
Nodoka Yasuda, Takayuki Ishii, Dai Oyama, Tatsuya Fukuta, Yurika Agato, Akihiko Sato, Kosuke Shimizu, Tomohiro Asai, Tomohiro Asakawa, Toshiyuki Kan, Shizuo Yamada, Yasushi Ohizumi, Naoto Oku
Brain Res., 1559, 46-54 (2014)

(111) 2-Azahypoxanthine and imidazole-4-carboxamide produced by the fairy-ring-forming fungus increases wheat yield
Hiroyuki Tobina, Jae-Hoon Choi, Tatsuo Asai, Yoshikazu Kiriiwa, Tomohiro Asakawa, Toshiyuki Kan, Akio Morita, Hirokazu Kawagishi
Field Crops Res., 162C, 6-11 (2014)

(110) Practical Total Synthesis of Acromelic acid A and B
Hitoshi Ouchi, Aya Asahina, Tomohiro Asakawa, Makoto Inai, Yoshitaka Hamashima, Toshiyuki Kan
Org. Lett., 16, 1980-1983 (2014)

(109) Stereocontrolled Total Synthesis of Hedyotol A
Yusuke Kawabe, Ryo Ishikawa, Yusuke Akao, Atsushi Yoshida, Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima, Toshiyuki Kan
Org. Lett., 16, 1976-1979 (2014)

(108) Enantioselective Synthesis of SB-203207
Yasuo Hirooka, Kazutada Ikeuchi, Yuichiro Kawamoto, Yusuke Akao, Takumi Furuta, Tomohiro Asakawa, Makoto Inai, Toshiyuki Wakimoto, Tohru Fukuyama, Toshiyuki Kan
Org. Lett., 16, 1646-1649 (2014)

(107) Use of positron emission tomography for real-time imaging of biodistribution of green tea catechin
Kosuke Shimizu, Tomohiro Asakawa, Norihiro Harada, Dai Fukumoto, Hideo Tsukada, Tomohiro Asai, Shizuo Yamada, Toshiyuki Kan, Naoto Oku
PLOS ONE, 9, e85520 (2014)

(106) The Source of "Fairy Rings": 2-Azahypoxanthine and its Metabolite Found in a Novel Purine Metabolic Pathway in Plants
Jae-Hoon Choi, Toshiyuki Ohnishi, Yasuhiro Yamakawa, Shogo Takeda, Shuhei Sekiguchi, Waki Maruyama, Kimiko Yamashita, Tomohiro Suzuki, Akio Morita, Takashi Ikka, Reiko Motohashi, Yoshikazu Kiriiwa, Hiroyuki Tobina, Tatsuo Asai, Shinji Tokuyama, Hirofumi Hirai, Nobuhiro Yasuda, Keiichi Noguchi, Tomohiro Asakawa, Shimpei Sugiyama, Toshiyuki Kan, Hirokazu Kawagishi
Angew. Chem. Int. Ed., 53, 1552-1555 (2014)

(105) Practical Synthesis of Kainoids: A New Chemical Probe Precursor and a Fluorescent Probe
Shingo Sasaki, Hiroto Suzuki, Hitoshi Ouchi, Tomohiro Asakawa, Makoto Inai, Yoshitaka Hamashima, Ryuichi Sakai, Keiko Shimamoto, Toshiyuki Kan
Org. Lett., 16, 564-567 (2014)

(104) Synthetic Studies of Fisetin, Myricetin and Nobiletin Analogs and Related Probe Molecules
Aiki Hiza, Yuta Tsukaguchi, Takahiro Ogawa, Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima, Toshiyuki Kan
Heterocycles, 88, 1371-1396 (2014)

(103) Stereocontrolled total synthesis of sphingofungin E
Kazutada Ikeuchi, Moemi Hayashi, Tomohiro Yamamoto, Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima, Toshiyuki Kan
Eur. J. Org. Chem., 2013, 6789 (2013)

(102) Chemical synthesis of tea polyphenols and related compounds
Tomohiro Asakawa, Yoshitaka Hamashima, Toshiyuki Kan
Current Pharmaceutical Design, 19, 6207 (2013)

(101) Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes
Misaka, Shingen; Kawabe, Keisuke; Onoue, Satomi; Werba, Jose Pablo; Giroli, Monica; Tamaki, Sekihiro; Kan, Toshiyuki; Kimura, Junko; Watanabe, Hiroshi; Yamada, Shizuo
Drug Metabolism and Pharmacokinetics, 28, 244-249 (2013)

(100) Physicochemical and biopharmaceutical characterization of amorphous solid dispersion of nobiletin, a citrus polymethoxylated flavone, with improved hepatoprotective effects
Satomi Onoue, Tatsuya Nakamura, Atsushi Uchida, Kazunori Ogawa, Kayo Yuminoki, Naofumi Hashimoto, Aiki Hiza, Yuta Tsukaguchi, Tomohiro Asakawa, Toshiyuki Kan, Shizuo Yamada
Euro. J. Pharm. Sci., 49, 453-460 (2013)

(99) Chemoselective Hydrogenation Reaction of Unsaturated Bonds in the Presence of o-Nitrobenzenesulfonyl Group
Akinori Kawanishi, Chiyako Miyamoto, Yuki Yabe, Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima, Hironao Sajiki, Toshiyuki Kan
Org. Lett., 15, 1306-1309 (2013)

(98) Synthesis of Theaflavins via Biomimetic Oxidative Coupling Reactions
Yusuke Kawabe, Yoshiyuki Aihara, Yoshitsugu Hirose, Asuka Sakurada, Atsushi Yoshida, Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima, Toshiyuki Kan
Synlett 24, 479-482 (2013)

(97) Stereocontrolled Total Synthesis of (-)-FR-901483
Shigeru Ieda, Akitaka Masuda, Mami Kariyama, Toshiyuki Wakimoto, Tomohiro Asakawa, Tohru Fukuyama, Toshiyuki Kan
Heterocycles, 86, 1071-1092 (2012)

(96) Catalytic Desymmetrization of Cyclohexadienes by Asymmetric Bromolactonization
Kazutada Ikeuchi, Shunsuke Ido, Satoshi Yoshimura, Tomohiro Asakawa, Makoto Inai, Yoshitaka Hamashima, Toshiyuki Kan
Org. Lett. 14, 6016-6019 (2012)

(95) Analysis of Nε-ethyllysine in human plasma proteins by gas chromatography-negative ion chemical ionization/mass spectrometry as a biomarker for exposure to acetaldehyde and alcohol
Ryota Mabuchi, Aya Kurita, Noriyuki Miyoshi, Akira Yokoyama, Takumi Furuta, Toshinao Goda, Yoshihide Suwa, Toshiyuki Kan, Takashi Amagai, Hiroshi Ohshima
Alcoholism: Clinical & Experimental Research, 36, 1013-1020 (2012)

(94) Stereocontrolled Total Synthesis of (+)- UCS1025A
Kenji Uchida, Takahiro Ogawa, Yoshinori Yasuda, Hiraku Mimura, Teppei Fujimoto, Tohru Fukuyama, Toshiyuki Wakimoto, Tomohiro Asakawa, Yoshitaka Hamashima, Toshiyuki Kan
Angew. Chem. Int. Ed. 51, 12850-12853 (2012)

(93) Total Synthesis of (–)-Lemonomycin
Atsushi Yoshida, Michinori Akaiwa, Yoshitaka Hamashima, Satoshi Yokoshima, Tohru Fukuyama, Toshiyuki Kan
Chem. Eur. J. 18, 11192-11195 (2012)

(92) A Short-Step Asymmetric Synthesis of Dehydrodiconiferyl Alcohol via C-H Insertion Reaction
Shogo Matsumoto, Tomohiro Asakawa, Yoshitaka Hamashima, Toshiyuki Kan
Synlett, 23, 1082-1084 (2012)

(91) 3,3’,4’,5,5’-Pentahydroxyflavone is a potent inhibitor of amyloid β fibril formation
Hiroko Ushikubo, Sayaka Watanabe, Yui Tanimoto, Kazuho Abe, Aiki Hiza, Takahiro Ogawa, Tomohiro Asakawa, Toshiyuki Kan, Tatsuhiro Akaishi
Neuroscience Letters, 513, 51-56 (2012)

(90) Furan fatty acid as an anti-inflammatory component from green-lipped mussel, Perna canaliculus
T. Wakimoto, H. Kondo, H, Nii, K. Kimura, Y. Egami, Y. Oka, M. Yoshida, E. Kida, Y. Ye, S. Akahoshi, T. Asakawa, K. Matsumura, H. Ishida, H. Nukaya, K. Tsuji, T. Kan, I. Abe
Proc. Natl. Acad. Sci. USA, 108, 17533-17537 (2011)

(89) Enantioselective Total Synthesis of Aperidine
Toshiyuki Wakimoto, Kakeru Miyata, Hitoshi Ouchi, Tomohiro Asakawa, Haruo Nukaya, Yoshihide Suwa, Toshiyuki Kan
Org. Lett., 13, 2789-2791 (2011)

(88) Stereocntrolled Synthesis of (+)-Methoxyphenylkainic acid and (+)-Phenylkainic acid
Takumi Higashi, Yoichiro Isobe, Hitoshi Ouchi, Hiroto Suzuki, Yuko Okazaki, Tomohiro Asakawa, Takumi Furuta, Toshiyuki Wakimoto, Toshiyuki Kan
Org. Lett., 13, 1089-1091 (2011)

(87) PET Imaging of Nobiletin Based on a Practical Total Synthesis
Tomohiro Asakawa, Aiki Hiza, Miho Nakayama, Makoto Inai, Dai Oyama, Hiroyuki Koide, Kosuke Shimizu, Toshiyuki Wakimoto, Norihiro Harada, Hideo Tsukada, Naoto Oku, Toshiyuki Kan
Chem. Commun., 47, 2868-2870 (2011)

(86) Anti-angiogenic activity and intracellular distribution of epigallalocatechin-3-gallate analogs
Suratsawadee PIYAVIRIYAKUL, Kosuke Shimizu, Tomohiro Asakawa, Toshiyuki Kan, Pongun SIRIPONG, Naoto Oku
Biol. Pharm. Bull., 34, 396-400 (2011)

(85) Concise synthesis of catechin probes enabling analysis and imaging of EGCg
Atsushi Yoshida, Yasuo Hirooka, Yusuke Sugata, Mariko Nitta, Tamiko Manabe, Shunsuke Ido, Kouki Murakami, Repon Kumer Saha, Takashi Suzuki, Motohiro Ohshima, Akira Yoshida, Kunihiko Itoh, Kosuke Shimizu, Naoto Oku, Takumi Furuta, Tomohiro Asakawa, Toshiyuki Wakimoto, Toshiyuki Kan
Chem. Commun., 47, 1794-1796 (2011)

(84) Proof the existence of an unstable amino acid, pleurocybellaziridine, in Pleurocybella porrigens (angel’s wing mushroom)
Toshiyuki Wakimoto, Tomohiro Asakawa, Saeko Akahoshi, Tomohiro Suzuki, Kaoru Nagai, Hirokazu Kawagishi, Toshiyuki Kan
Angew. Chem. Int. Ed., 50, 1168-1170 (2011)

(83) Diblock Copolymer of Bacterial Cellulose and Poly(methyl methacrylate) Initiated by Chain-End-Type Radicals Produced by Mechanical Scission of Glycosidic Linkages of Bacterial Cellulose
Sakaguchi, Masato; Ohura, Takeshi; Iwata, Tadahisa; Takahashi, Shuhei; Akai, Shuji; Kan, Toshiyuki; Murai, Hisao; Fujiwara, Motoyasu; Watanabe, Osamu; Narita, Mamiko.
Biomacromolecules, 11, 3059-3066 (2010)

(82) Synthesis of Axially Chiral Amino Acid and Amino Alcohols via Additive-Ligand-Free Pd-Catalyzed Domino Coupling Reaction and Subsequent Transformations of the Product Amidoaza[5]helicene
Furuta, Takumi; Yamamoto, Junya; Kitamura, Yuki; Hashimoto, Ayano; Masu, Hyuma; Azumaya, Isao; Kan, Toshiyuki; Kawabata, Takeo.
J. Org. Chem., 75, 7010-7013 (2010)

(81) Synthesis of the Optically Active Key Intermediate of FR901483
Shigeru Ieda, Toshiyuki Kan, Tohru Fukuyama
Tetrahedron Lett. 51, 4027-4029 (2010)

(80) Structural characteristics of green tea catechins for formation of protein carbonyl in human serum albumin
Takeshi Ishii, Taiki Mori, Tatsuya Ichikawa, Maiko Kaku, Koji Kusaka, Yoshinori Uekusa, Mitsugu Akagawa, Yoshiyuki Aihara, Takumi Furuta, Toshiyuki Wakimoto, Toshiyuki Kan, Tsutomu Nakayama
Bioorg. Med. Chem., 18, 4892-4896 (2010)

(79) Binding affinity of tea catechins for human serum albumin: Characterization by high-performance affinity chromatography with immobilized albumin column
Takeshi Ishii, Kanako Minoda, Min-Jung Bae, Taiki Mori, Yoshinori Uekusa, Tatsuya Ichikawa, Yoshiyuki Aihara, Takumi Furuta, Toshiyuki Wakimoto, Toshiyuki Kan, Tsutomu Nakayama
Mol. Nutr. Food Res., 54, 816-822 (2010)

(78) Modified Julia-Kocienski Reaction Promoted by Means of m-NPT (Nitrophenyltetrazole) sulfone
Yuki Sakai, Kazutada Ikeuchi, Yuji Yamada, Toshiyuki Wakimoto, Toshiyuki Kan
Synlett, 22, 827-827 (2010)

(77) Reaction Behavior of Cumulene: Diels-Alder, Friedel-Crafts, and Pd-Catalyzed Domino Reactions
Tomohiro Asakawa, Mie Iinuma, Yuko Wakasugi, Mayumi Kuno, Takumi Furuta, Satoshi Fujii, Kiyoshi Tanaka, Toshiyuki Kan
Heterocycles, 80, 1125-1147 (2010)

(76) Development of Photoaffinity Probes for g-Secretase Equipped with a Nitrobenzenesulfonamide-type Cleavable Linker
Satoshi Yokoshima, Yuzo Abe, Naoto Watanabe, Yoichi Kita, Toshiyuki Kan, Takeshi Iwatsubo, Taisuke Tomita, Tohru Fukuyama
Bioorg. Med. Chem. Lett., 19, 6869-6871 (2009)

(75) Solid Support Synthesis of Artificial Phospholipids
Takumi Furuta, Hitoshi Onuki, Masayoshi Mochizuki, Mai Ito, Makoto Inai, Toshiyuki Wakimoto, Toshiyuki Kan
Synlett, 3373-3377 (2009)

(74) Structure-activity relationship study on a 1 adrenergic receptor antagonists from beer
Toshiyuki Wakimoto, Makoto Nitta, Kana Kasahara, Taketo Chiba, Yiping Ye, Kuniro Tsuji, Toshiyuki Kan, Haruo Nukaya, Masaji Ishiguro, Minako Koike, Yoshiaki Yokoo, Yoshihide Suwa
Bioorg. Med. Chem. Lett., 19, 5905-5908 (2009)

(73) Regioselective Synthesis of Methylated Epigallocatechin Gallate via Nitrobenzenesulfonyl (Ns) Protecting Group
Yoshiyuki Aihara, Atsusi Yoshida, Takumi Furuta, Toshiyuki Wakimoto, Toshifumi Akizawa, Motomi Konishi, Toshiyuki Kan
Bioorg. Med. Chem. Lett., 19, 4171-4174 (2009)

(72) Stereocontrolled Total Synthesis of (±)-FR901483
S. Ieda, Y. Asoh, T. Fujimoto, H. Kitaoka, T. Kan, T. Fukuyama
Heterocycles, 79, 721-738 (2009)

(71) Concise Synthesis of Chafurosides A and B
T. Furuta, M. Nakayama, H. Suzuki, H. Tajimi, M. Inai, H. Nukaya, T. Wakimoto, T. Kan
Org. Lett., 11, 2233-2236 (2009)

(70) Identification and characterization of flavonoids as sialyltransferase inhibitors
K. I.P.J. Hidari, K. Oyama, G. Ito, M. Nakayama, M. Inai, S. Goto, Y. Kanai, K. Watanabe, K. Yoshida, T. Furuta, T. Kan, T. Suzuki
Biochemical and Biophysical Research Communications, 380, 609-613 (2009)

(69) Total Synthesis of (±)-Morphine
Kenji Uchida, Satoshi Yokoshima, Toshiyuki Kan, Tohru Fukuyama
Heterocycles, 77, 1219-1234 (2009)

(68) Stereocontrolled Total Synthesis of (–)-Myriocin
M. Inai, T. Goto, T. Furuta, T. Wakimoto, T. Kan
Tetrahedron Asymmetry, 19, 2771-2773 (2008)

(67) Total Synthesis of (–)-Serotobenine
Y. Koizumi, H. Kobayashi, T. Wakimoto, T. Furuta, T. Fukuyama, T. Kan
J. Am. Chem. Soc., 130, 16854-16855 (2008)

(66) Efficient Synthesis of Optically Active Gallocatechin-3-gallate Derivatives via 6-endo Cyclization
Yasuo Hirooka, Mariko Nitta, Takumi Furuta, Toshiyuki Kan
Synlett, 3234-3237 (2008)

(65) Versatile Synthesis of Head Group Functionalized Phospholipids via Oxime Bond Formation
Takumi Furuta, Masayoshi Mochizuki, Mai Ito, Tadanobu Takahashi, Takashi Suzuki, Toshiyuki Kan
Org. Lett., 10, 4847-4850 (2008)

(64) Tackling Alzheimer’s disease by means of original synthetic methodologies in organic chemistry
T. Kan, T. Fukuyama
J. Syn. Org. Chem., Jpn, 66, 765-773 (2008)

(63) Synthetic Studies on (+)-Manzamine A: Stereoselective Synthesis of the Tetracyclic Core Framework
Y. Kita, T. Toma, T. Kan, T. Fukuyama
Org. Lett., 10, 3251-3253 (2008)

(62) Synthesis and characteristic stereostructure of biphenanthryl ether
Y. Koizumi, S. Suzuki, K. Takeda, K. Murahashi, M. Horikawa, K. Katagiri, H. Masu, I. Azumaya, S. Fujii, T. Furuta, K. Tanaka, T. Kan
Tetrahedron: Asymmetry, 19, 1407-1410 (2008)

(61) Synthesis of diazirine possessing an acetophenone derivative as a valuable intermediate for a flavonoid photoaffinity probe
T. Furuta, M. Ueda, Y. Hirooka, K. Tanaka, T. Kan
Heterocycles, 76, 811-817 (2008)

(60) One-pot Synthesis of Carbazole via Tandem Suzuki-Miyaura and Amination Reaction
Y. Kitamura, S. Yoshikawa, T. Furuta, T. Kan
Synlett, 377-380 (2008)

(59) Synthetic Studies on Altemicidin: Stereocontrolled Construction of the Core Framework
T. Kan, Y. Kawamoto, T. Asakawa, T. Furuta, T. Fukuyama
Org. Lett., 10, 169-171(2008)

(58) A Versatile Synthesis of a-Amino Acid Derivatives via The Ugi Four-Component Condensation with a Novel Convertible Isonitrile
K. Rikimaru, A. Yanagisawa, T. Kan, T. Fukuyama
Heterocycles, 73, 403-417 (2007)

(57) Divergent Synthesis of Multifunctional Molecular Probes Enabled Elucidation of the Enzyme Specificity of Dipeptidic g-Secretase Inhibitors on Presenilin-Type Aspartic Proteases
H. Fuwa, Y. Takahashi, Y. Konno, N. Watanabe, H. Miyashita, M. Sasaki, H. Natsugari, T. Kan, T. Fukuyama, T. Tomita, T. Iwatsubo
ACS Chemical Biology, 2, 408-418 (2007)

(56) Convenient Synthesis of Photoaffinity Probes and Evaluation of Their Labeling Abilities
T. Kan, Y. Kita, Y. Morohashi, Y. Tominari, S. Hosoda, H. Natsugari, T. Tomita, T. Iwatsubo, T. Fukuyama
Org. Lett., 9, 2055-2058 (2007)

(55) Copper-catalyzed enantioselective conjugate addition of diethylzinc using axially chiral aminoethyloxy-phosphine ligands
T. Morimoto, N. Obara, I. Yoshida, K. Tanaka, T. Kan
Tetrahedron Lett., 48, 3093-3095 (2007)

(54) Concise synthesis of dideoxy-epigallocatechin gallate (DO-EGCG) and evaluation of its anti-influenza virus activities
T. Furuta, Y. Hirooka, A. Abe, Y. Sugata, M. Ueda, K. Murakami, T. Suzuki, K. Tanaka, T. Kan
Bioorg. Med. Chem. Lett., 17, 3095-3098 (2007)

(53) Efficient Synthesis of Phenanthridinone Derivatives via a Palladium-Catalyzed Coupling Process
T. Furuta, Y. Kitamura, A. Hashimoto, S. Fujii, K. Tanaka, T. Kan
Org. Lett., 9, 183-186 (2007)

(52) Total Synthesis of (±)-Morphine
K. Uchida, S. Yokoshima, T. Kan, T. Fukuyama
Org. Lett., 8, 5311-5313 (2006)

(51) Domino Heck-C-H- Activaeion Reaction of Unsymmetrically Substitute[3]Cumulene
T. Furuta, T. Asakawa, M. Iinuma, S. Fujii, K. Tanaka, T. Kan
Chem. Commun., 3648-3650 (2006)

(50) Synthesis of Bicyclo[3.3.0]octane ring system via Desymmetric C-H Insertion Reaction
T. Kan, T. Inoue, Y. Kawamoto, M. Yonehara, T. Fukuyama
Synlett, 1583-1585 (2006)

(49) Synthesis of biotinylated photoaffinity probes based on arylsulfonamide g-secretase inhibitors
H. Fuwa, K. Hiromoto, Y. Takahashi, S. Yokoshima, T. Kan, T. Fukuyama, T. Iwatsubo, T. Tomita, H. Natsugari
Bioorg. Med. Chem. Lett., 16, 4184-4189 (2006)

(48) Novel g-secretase inhibitors discovered by screening in-house natural product synthesis intermediates library
Y. Takahashi, H. Fuwa, A. Kaneko, M. Sasaki, S. Yokoshima, H. Koizumi, T. Takebe, T. Kan, T. Iwatsubo, T. Tomita, H. Natsugari, T. Fukuyama
Bioorg. Med. Chem. Lett., 16, 3813-3816 (2006)

(47) Reaction behavior of cumulene on Diels-Alder and Friedel-Crafts reaction
T. Asakawa, M. Iinuma, T. Furuta, S. Fujii, T. Kan, K. Tanaka
Chem. Lett., 512-513 (2006)

(46) Carboxy-terminal fragment of Presenilin 1 is the molecular target of a dipeptidic g-secretase-specific inhibitor DAPT
Y. Morohashi, T. Kan, Y. Tominari, H. Fuwa, Y. Okamura, N. Watanabe, H. Natsugari, T. Fukuyama, T. Iwatsubo, T. Tomita
J. Biol. Chem., 281, 14670-14676 (2006)

(45) Synthesis of novel phenylnaphthyl phosphines and their applications to Pd-catalyzed amidation
Y. Kitamura, A. Hashimoto, S. Yoshikawa, J. Odaira, T. Furuta, T. Kan, K. Tanaka
Synlett, 115-117 (2006)

(44) Synthetic Studies on (–)-Lemonomycin: Stereocontrolled Construction of the 3,8-Diazabicyclo[3.2.1] Skeleton
K. Rikimaru, K. Mori, T. Kan, T. Fukuyama
Chem. Commun., 394-396 (2005)

(43) Acetoxy Group Directed Cyclization Promoted by SmI2: Directing Group Determined Stereocomplementarity
T. Kan, S. Hosokawa, S. Nara, H. Tamiya, H. Shirahama, F. Matsuda
J. Org. Chem., 69, 8956-8958 (2004)

(42) Total Synthesis of (–)-Ephedradine A (Orantine): An Efficient Construction of Optically Active Dihydrobenzofuran-ring via C-H Insertion Reaction
W. Kurosawa, H. Kobayashi, T. Kan, Tohru Fukuyama
Tetrahedron, 60, 9615-9628 (2004)

(41) Synthetic Studies on (+)-Naphthyridinomycin: Stereoselective Synthesis of the Tetracyclic Core Framework
K. Mori, K. Rikimaru, T. Kan, T. Fukuyama
Org. Lett., 6, 3095-3097 (2004)

(40) Stereocontrolled Total Synthesis of Potent Immunosuppressant FR901483
T. Kan, T. Fujimoto, Y. Asoh, S. Ieda, H. Kitaoka, T. Fukuyama
Org. Lett., 6, 2729-2731 (2004)

(39) Stereoselective Nucleophilic Addition Reaction with a New Chiral Template and Its Application to Synthesis of Optically Active a-Arylglycine Derivatives
S. Tohma, K. Rikimaru, A. Endo, T. Kan, T. Fukuyama
Synthesis, 909-917 (2004)

(38) Highly efficient synthesis of medium-sized lactams via intramolecular Staudinger-aza-Wittig reaction of ω-azide pentaphenyl ester: synthesis and biological evaluation of LY411575 analogues
H. Fuwa, Y. Okamura, Y. Morohashi, T. Tomita, T. Iwatsubo, T. Kan, T. Fukuyama, H. Natsuari
Tetrahedron Lett., 45, 2323-2326 (2004)

(37) Parallel Synthesis of DAPT Derivatives and Their g-Secretase-Inhibitory Activity
T. Kan, Y. Tominari, K. Rikimaru, Y. Morohashi, H. Natsugari, T. Tomita, T. Iwatsubo, T. Fukuyama
Bioorg. Med. Chem. Lett.,14, 1983-1985 (2004)

(36) Ns Strategies: A Highly Versatile Synthetic Method for Amines
T. Kan, T. Fukuyama
Chem. Commun., 353-359 (2004)

(35) A Versatile Synthesis of a-Amino Acid Derivatives via the Ugi Four-Component Condensation with a Novel Convertible Isonitrile
K. Rikimaru, A. Yanagisawa, T. Kan, T. Fukuyama
Synlett, 41-44 (2004)

(34) Total Synthesis of Potent Antitumor Alkaloid Ecteinascidin 743
T. Kan
J. Syn. Org. Chem., Jpn, 61, 949-960 (2003)

(33) Solid-Phase Synthesis of Photoaffinity Probes: Highly Efficient Incorporation of Biotin-tag and Cross-linking group
T. Kan, Y. Tominari, Y. Morohashi, H. Natsugari, T. Tomita, T. Iwatsubo, T. Fukuyama
Chem. Commun., 2244-2245 (2003)

(32) Stereocontrolled Total Synthesis of (–)-Ephedradine A (Orantine)
W. Kurosawa, T. Kan, T. Fukuyama
J. Am. Chem. Soc., 125, 8112-8113 (2003)

(31) Sulindac sulfide is a non-competitive g-secretase inhibitor that preferentially reduces Ab42 generation
Y. Takahashi, I. Hayashi, Y. Tominari, K. Rikimaru, Y. Morohashi, T. Kan, H. Natsugari, T. Fukuyama, T. Tomita, T. Iwatsubo
J. Bio. Chem., 278, 18664-18670 (2003)

(30) An Efficient Synthesis of Optically Active trans-2-Aryl-2,3-dihydrobenzofuran-3-carboxylic Acid Esters via C-H Insertion Reaction
W. Kurosawa, T. Kan, T. Fukuyama
Synlett, 1028-1030 (2003)

(29) Preparation of Secondary Amines from Primary Amines via 2-Nitrobenzenesulfonamides: N-(4-Methoxybenzyl)-3-phenylpropylamine
W. Kurosawa, T. Kan, T. Fukuyama
Org. Synth., 79, 186 (2002)

(28) Highly Versatile Synthesis of Polyamines by the Ns-strategy on a Novel Trityl Chloride Resin
T. Kan, H. Kobayashi, T. Fukuyama
Synlett, 1338-1340 (2002)

(27) Efficient Macrocyclization by Means of 2 Nitrobenzenesulfonamide and Total Synthesis of Lipogrammistin-A
T. Kan, A. Fujiwara, H. Kobayashi, T. Fukuyama
Tetrahedron, 58, 6267-6276 (2002)

(26) Total Synthesis of Ecteinascidin 743
A. Endo, A. Yanagisawa, M. Abe, S. Tohma, T. Kan, T. Fukuyama
J. Am. Chem. Soc., 124, 6552-6554 (2002)

(25) Efficient Synthesis of Medium-Sized Cyclic Amines by Means of 2-Nitrobenzenesulfonamide
T. Kan, H. Kobayashi, T. Fukuyama
Synlett, 697-699 (2002)

(24) Highly Versatile Synthesis of Nitrogen-Containing Compounds by Means of Nitrobenzene-sulfon-amides
T. Kan, T. Fukuyama
J. Syn. Org. Chem., Jpn, 59, 779-789 (2001)

(23) Dogger Bank Itch revisited: isolation of (2-hydroxyethyl) dimethylsulfoxonium chloride as a cytotoxic constituent from the marine sponge Theonella aff. Mirabilis
K. Warabi, Y. Nakao, S. Matsunaga, T. Fukuyama, T. Kan, S. Yokoshima, N. Fusetani
Comp. Biochem. Physiol., 128B, 27-30 (2001)

(22) Synthesis of Optically Active Arylglycines: Stereoselective Mannich Reaction of Phenols with a New Chiral Template
S. Tohma, A. Endo, T. Kan, T. Fukuyama
Synlett, 1179-1181 (2001)

(21) Total Synthesis of Lipogrammistin-A: Efficient Macrocyclization with 2-Nitrobenzene-sulfonamide
A. Fujiwara, T. Kan, T. Fukuyama
Synlett, 1667-1669 (2000)

(20) Total Synthesis of Polyamine Toxin HO-416b ang Agel-489 Using a 2-Nitrobenzene-sulfonamide Strategy
Y. Hidai, T. Kan, T. Fukuyama
Chem. Pharm. Bull., 48, 1570-1576 (2000)

(19) Hydroxy-Directed, SmI2-Induced Conversion of Carbohydrates into Carbocycles
T. Kan, S. Nara, T. Ozawa, H. Shirahama, F. Matsuda
Angew. Chem. Int. Ed., 39, 355 (2000)

(18) N-Carboalkoxy-2-Nitrobenzenesulfonamides: A Practical Preparation of N-Boc-, N-Alloc-, and N-Cbz-Protected Primary Amines
T. Fukuyama, M. Cheung, T. Kan
Synlett, 1301-1303 (1999)

(17) Synthetic Study on Ecteinascidin 743 Starting from D-Glucose
A. Endoh, T. Kan, T. Fukuyama
Synlett, 1103-1105 (1999)

(16) Total Synthesis of Polyamine Toxin HO-416b Utilizing the 2-Nitrobenzenesulfonamide Protecting Group
Y. Hidai, T. Kan, T. Fukuyama
Tetrahedron Lett., 40, 4711 (1999)

(15) Internal Activation of Acrylate-Type Dienophiles in Diels-Alder Reactions. Stereselective Synthesis of Conformationally Constrained Glutamate Analogs
Y. Ohfune, T. Kan, T. Nakajima
Tetrahedron, 54, 5207-5224 (1998)

(14) Asymetric Syntheses of 5- and 6-Membered carbocyclic Serine Analogs via an Intermolecular Strecker Synthesis
Y. Ohfune, K. Nanba, I. Takada, T. Kan, M. Horikawa, T. Nakajima
Chirality, 9, 459 (1997)

(13) 2,4-Dinitrobenzenesulfonamides: A Simple and Practical Method for the Preparation of Secondary Amines and Diamines
T. Fukuyama, M. Cheung, C. -K. Jow, Y. Hidai, T. Kan
Tetrahedron Lett., 38, 5831-5834 (1997)

(12) Efficient Syntheses of Amadori Rearrangement Compounds
T. Iwamoto, T. Kan, S. Katsumura, Y. Ohfune
Synlett, 169-170 (1996)

(11) Internal Activation of Acrylate-Type Dienophiles in Diels-Alder Reactions
T. Kan, Y. Ohfune
Tetrahedron Lett., 36, 943-946 (1995)

(10) Synthetic Studies on Grayanotoxins. Diastereofacially Selective Dieles-Alder Reaction of 4-Bebzyloxy-2-pentenoate
T. Kan, M. Oikawa, S. Hosokawa, M. Yanagiya, F. Matsuda, H. Shirahama
Synlett, 801-804 (1994)

(9) Synthetic Studies on Grayanotoxins. Stereocontrolled Construction of CD-Ring of Grayanotoxins
T. Kan, M. Oikawa, S. Hosokawa, M. Yanagiya, F. Matsuda, H. Shirahama
Synlett, 805-808 (1994)

(8) Total Synthesis of (-)-Grayanotoxin (III)
T. Kan, S. Hosokawa, S. Nara, M. Oikawa, S Ito, F. Matsuda, H. Shirahama
J. Org. Chem., 59, 5532-5534 (1994)

(7) Stereoselective Cyclization Mediated by Samarium (II) Iodide Using Allyl Sulfides and Sulfones as Ketyl Radical Acceptors
T. Kan, S. Nara, S. Ito, F. Matsuda, H. Shirahama
J. Org. Chem., 59, 5111-5111 (1994)

(6) Stereocontrolled Construction of B-Ring of Grayanotoxins via Samarium (II) Iodide Promoted Pinacol Coupling Cyclization
T. Kan, F. Matsuda, M. Yanagiya, H. Shirahama
Synlett, 391-392 (1991)

(5) Total Synthesis of (+)-Thrsiferol, (+)-Thyrsiferyl 23-Acetate and Venustatriol
M. Hashimoto, T. Kan, K. Nozaki, M. Yanagiya, H. Shirahama, T. Matsumoto
J. Org. Chem., 59, 5088-5107 (1990)

(4) Formation of Bicyclo[4.2.0]octane System from Cyclooctenyl Cation Equivalent. Biomimetic Cyclization of Humulene to Protoilludane Derivaties
T. Takatsu, S. Ito, T. Kan, H. Shirahama, T. Matsumoto
Synlett, 40-42 (1989)

(3) Effective Deprotection of 2-(Trimethylsilylethoxy)methlated Alchols (SEM ethers), Synthesis of (+)-Thyrsiferyl 23-Acetate
T. Kan, M. Hashimoto, M. Yanagiya, H. Shirahama
Tetrahedron. Lett., 29, 5417-5418 (1988)

(2) Total Synthesis of (+)-Thrsiferol and Venustatriol
M. Hashimoto, T. Kan, K. Nozaki, M. Yanagiya, H. Shirahama, T. Matsumoto
Tetrahedron Lett., 29, 1143-1144 (1988)

(1) Synthesis of A-B-C-Ring Segment of Thrsiferoll. Construction of a Strained Tetrahydropyran Ring Existenece as a Boat Form
M. Hashimoto, T. Kan, M. Yanagiya, H. Shirahama, T. Matsumoto
Tetrahedron Lett., 28, 5565-5668 (1987)