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トップページ >  English >  CV >  Assistant Professor Makoto INAI, Ph.D

Assistant Professor Makoto INAI, Ph.D


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INAI, Makoto, Ph.D

Current Address

School of Pharmaceutical Sciences
University of Shizuoka
52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan

Phone: 81-54-264-5741
Fax: 81-54-264-5745

e-mail: makinai(@)u-shizuoka-ken.ac.jp

Education and Research Positions

9/2011-Present: Assistant professor, School of Pharmaceutical Sciences
University of Shizuoka (Professor T. Kan Group)
4/2011-8/2011: Assistant professor, Factually of Pharmaceutical Sciences
Tokushima Bunri University (Professor T. Tsunoda Group)
4/2010-3/2011: Postdoctoral Fellow, Factually of Pharmaceutical Sciences
Tokushima Bunri University (Professor Tetsuto Tsunoda)
4/2009-3/2010: Uehara Memorial Foundation, Postdoctoral Fellow Department of Chemistry
Colorado State University (Professor Robert M. Williams)
4/2006-3/2009: D. S., School of Pharmaceutical Sciences
University of Shizuoka (Professor Toshiyuki Kan)

Publication

Paper
(38) “Stereospecific Construction of 2-Vinyl 3-Hydroxybenzopyrane Rings: Total Synthesis of Teadenol A and B” Yoshida, R.; Ouchi, H.; Asakawa, T.; Inai, M.; Egi, E.; Hamashima, Y.; Kan, T. Org. Biomol. Chem. 2016, in press.

(37) “Concise synthesis of anserine: efficient solvent tuning in asymmetric hydrogenation reaction” Yamashita, M.; Shimizu, K.; Wakimoto T.; Hamashima, Y.; Asakawa T.; Inai, M.; Kan, T. Chem. Pharm. Bull. 2016, in press.

(36) “Synthesis of chemical-biology tools enabling in vivo imaging and analysis of epigallocatechin gallate.” Asakawa, T.; Yoshida, A.; Hirooka, Y.; Suzuki, T.; Itoh, K.; Shimizu, K.; Oku, N.; Furuta, T.; Wakimoto, T.; Inai M.; Kan T. Heterocycles 2016 in press.

(35) “Practical synthesis of spermine, thermospermine and norspermine” Kariya, Y.; Asanuma, Y.; Inai, M.; Asakawa, T.; Ohashi-Ito, K.; Fukuda, H.; Egi, M.; Kan, T. Chem. Pharm. Bull. 2016, 64, 1403–1407.

(34) “Practical Total Syntheses of Acromelic Acids A and B” Inai, M.; Ouchi, H.; Asahina, A.; Asakawa, T.; Hamashima, Y.; Kan, T. Chem. Pharm. Bull. 2016, 64, 723–732.

(33) “Synthesis of food effective constituents toward the development for chemical biology investigations” Inai, M.; Asakawa, T.; Kan, T. J. Syn. Org. Chem., Jpn. 2016, 74, 412–425.

(32) “SYNTHESES OF METHYLATED CATECHINS AND THEAFLAVINS USING 2-NITROBENZENESULFONYL GROUP TO PROTECT AND DEACTIVATE PHENOL” Kan, T; Asakawa, T.; Kawabe, Y.; Yoshida, A.; Aihara, Y.; Manabe, T.; Hirose, Y.; Sakurada, A.; Inai, M.; Hamashima, Y.; Furuta, T.; Wakimoto, T. J. Antibiot. 2016, 69, 299–312.

(31) “Applications of C–H Insertion Reaction in Total Synthesis of Biologically Active Heterocyclic Natural Products” Kan, T.; Asakawa, T.; Inai, M. Heterocycles 2016, 92, 31–43.

(30) “Stereocontrolled Total Syntheses of Optical Active Furofuran Lignans” Inai, M.; Ishikawa, R.; Yoshida, N.; Akao, Y.; Kawabe, Y.; Shirakawa, N.; Asakawa, T.; Egi, M.; Hamashima, Y.; Kan, T. Synthesis 2015, 47, 3513–3521.

(29) “Isolation and total syntheses of cytotoxic cryptolactone A1, A2, B1 and B2: α,β-unsaturated δ-lactones from the aphid Cryptomyzus sp.” Horikawa, M.; Inai, M.; Ogri, Y.; Kuroda, E.; Tanaka, M.; Suzuki, S.; Ito, T.; Takahashi, S.; Kaku, H.; Tsunoda, T. J. Nat. Prod. 2014, 77, 2459−2464.

(28) “Total Syntheses of (+)-Sesamin and (+)-Sesaminol” Ishikawa, R.; Yoshida, N.; Akao, Y.; Kawabe, Y.; Inai, M.; Asakawa, T.; Hamashima, Y.; Kan, T. Chem. Lett. 2014, 43, 1572–1574. [Editor’s choice and open access article]

(27) “Practical synthesis of natural plant-growth regulator 2-azahypoxanthine, its derivatives, and biotin-labeled probes” Ikeuchi, K.; Fujii, R.; Sugiyama, S.; Asakawa, T.; Inai, M.; Hamashima, Y.; Choi, J.; Suzuki, T.; Kawagishi, H.; Kan, T. Org. Biomol. Chem. 2014, 12, 3813–3815.

(26) “Stereocontrolled total synthesis of Hedyotol A” Kawabe, Y.; Ishikawa, R.; Yoshida, A; Inai, M.; Asakawa, T.; Hamashima, Y.; Kan, T. Org. Lett. 2014, 16, 1980–1983.

(25) “Practical Total Synthesis of Acromelic acid A and B” Ouchi, H.; Asahina, A.; Asakawa, T.; Inai, M.; Hamashima, Y.; Kan, T. Org. Lett. 2014, 16, 1976–1979.

(24) “Total Synthesis of (–)-SB-203207” Hirooka, Y.; Ikeuchi, K.; Kawamoto, Y.; Akao, Y.; Furuta, T.; Asakawa, T.; Inai, M.; Wakimoto, T.; Fukuyama, T.; Kan, T. Org. Lett. 2014, 16, 1646–1649.

(23) “Practical Synthesis of Kainoids: A New Chemical Prove Precursor and a Fluorescent Probe” Sasaki, S.; Suzuki, H.; Ouchi, H. Asakawa, T.; Inai, M.; Sakai, R.; Shimamoto, K.; Hamashima, Y.; Kan, T. Org. Lett. 2014, 16, 564−567.

(22) “Synthetic study of Flavonoid and its Chemical Probes” Hiza, A.; Tsukaguchi, Y.; Ogawa, T.; Inai, M.; Asakawa, T.; Hamashima, T.; Kan, T. Heterocycles 2014, 88, 1371–1396.

(21) “A Method to Prepare Optically Active Acyclic -Benzylketones by Thermodynamically Controlled Deracemization” Kaku, H.; Imai, T.; Kondo, R.; Mamba, S.; Watanabe, Y.; Inai, M.; Nishii, T.; Horikawa, H.; Tsunoda, T. Eur. J. Org. Chem. 2013, 8208–8213.

(20) “Stereocontrolled total synthesis of sphingofungin E” Ikeuchi, K.; Hayashi, M.; Yamamoto, T.; Inai, M.; Asakawa, T.; Hamashima, Y.; Kan, T. Eur. J. Org. Chem. 2013, 6789–6792.

(19) “Chemoselective Hydrogenation Reaction of Unsaturated Bonds in the Presence of o-Nitrobenzenesulfonyl Group” Kawanishi, A.; Miyamoto, C.; Yabe, Y.; Inai, M.; Asakawa, T.; Hamashima, Y.; Sajiki, H.; Kan, T. Org. Lett. 2013, 15, 1306–1309.

(18) “Xanthouroleuconaphin: a yellowish pigment from the aphid Uroleucon nigrotuberculatum and its total synthesis” Nishimura, T.; Horikawa, M.; Yamada, K.; Sogabe, A.; Nishii, T.; Kaku, H.; Inai, M.; Tanaka, M.; Takahashi, S.; Tsunoda, T. Tetrahedron 2013, 69, 1808–1814.

(17) “Synthesis of Theaflavins via Biomimetic Oxidative Coupling Reaction” Kawabe, Y.; Aihara, Y.; Hirose, Y.; Sakurada, A.; Yoshida, A.; Inai, M.; Asakawa, T.; Hamashima, Y.; Kan, T. Synlett 2013, 24, 479–482.

(16) “Catalytic Desymmetrization of Cyclohexadienes by Asymmetric Bromolactonizatio” Ikeuchi, K.; Ido, S.; Yoshimura, S.; Asakawa, T.; Inai, M.; Hamashima, Y.; Kan, T. Org. Lett. 2012, 14, 6016–6019.

(15) “A Total Synthesis of Yellowish Aphid Pigment Furanaphin through Fries Rearrangement Assisted by Boron Trifluoride-Acetic Acid Complex” Nishimura, T.; Iwata, T.; Maegawa, M.; Nishii, T.; Matsugasako, M.; Kaku, H.; Horikawa, M.; Inai, M.; Tsunoda, T. Synlett 2012, 23, 1789–1792.

(14) “Construction of an Asymmetric Quaternary Carbon by Asymmetric Aza-Claisen Rearrangement and its Application to a Total Synthesis of (+)-alpha-Cuparenone” Nishii, T.; Miyamae, F.; Yoshizuka, M.; Kaku, H.; Horikawa, M.; Inai, M.; Tsunoda, T. Tetrahedron: Asymmetry 2012, 23, 739–741.

(13) “Megouraphin Glucoside: Two Yellowish Pigments from the Aphid Megoura crassicauda Mordvilko” Horikawa, M.; Kikuchi, D.; Imai, T.; Tanaka, M.; Kaku, H.; Nishii, T.; Inai, M.; Takahashi, S.; Tsunoda, T. Heterocycles 2012, 85, 95–101.

(12) “Promotion of Asymmetric Aza-Claisen Rearrangement of N-Allylic Carboxamides Using Excess Base” Yoshizuka, M.; Nishii, T.; Sasaki, H.; Kitakado, J.; Ishigaki, N.; Okugawa, S.; Kaku, H.; Horikawa, M.; Inai, M.; Tsunoda, T. Synlett 2011, 2967–2970.

(11) “Viridaphin A1 Glucoside, a Green Pigment Possessing Cytotoxicity and Antibacterial Activity from the Aphid Megoura crassicauda Mordvilko” Horikawa, M.; Hoshiyama, T.; Matsuzawa, M.; Shugyo, T.; Tanaka, M.; Suzuki, S.; Sato, M.; Ito, T.; Asakawa, Y.; Kaku, H.; Nishii, T.; Inai, M.; Takahashi, S.; Tsunoda, T. J. Nat. Prod. 2011, 74, 1812–1816.

(10) “Total Synthesis of (+)-Brefeldin C utilizing aza-Claisen Rearrangement” Inai, M.; Nishii, T.; Mukoujima, S.; Esumi, T.; Kaku, H.; Tominaga, K.; Abe, H.; Horikawa, M.; Tsunoda, T. Synlett 2011, 1459–1461.

(9) “Total Synthesis of (+)-Antimycin A Family” Inai, M.; Nishii, T.; Tanaka, A.; Kaku, H.; Horikawa, M.; Tsunoda, T. Eur. J. Org. Chem. 2011, 2719–2729.

(8) “PET Imaging Investigation of Nobiletin Based on a Practical Total Synthesis” Asakawa, T.; Hiza, A.; Nakayama, M.; Inai, M.; Oyama, D.; Koide, H.; Shimizu, K.; Wakimoto, T.; Harada, N.; Tsukada, H.; Oku, N.; Kan, T. Chem. Commun. 2011, 47, 2868–2870.

(7) “Synthetic Studies on Palau’amine Construction of the Cyclopentane Core via an Asymmetric 1,3-Dipolar Cycloaddition” Namba, K.; Inai, M.; Sundermeier, U.; Greshock, T. J.; Williams R. M. Tetrahedron Lett. 2010, 51, 6557–6559.

(6) “A facile and practical method of preparing optically active α-monosubstituted cycloalkanones by thermodynamically controlled deracemization” Kaku, H.; Nakamaru, A.; Inai, M.; Nishii, N.; Horikawa, M.; Tsunoda, T. Tetrahedron 2010, 66, 9450–9455.

(5) “Solid Support Synthesis of Artificial Phospholipids” Furuta, T.; Onuki, H.; Mochizuki, M.; Ito, M.; Inai, M.; Wakimoto, T.; Kan, T. Synlett 2009, 3373–3374.

(4) “Concise Synthesis of Chafurosides A and B” Furuta, T.; Nakayama, M.; Suzuki, H.; Tajimi, H.; Inai, M.; Nukaya, H.; Wakimoto, T.; Kan, T. Org. Lett. 2009, 11, 2233–2236.

(3) “Identification and characterization of flavonoids as sialyltransferase inhibitors” Hidari, K. I. P. J.; Oyama, K.; Ito, G.; Nakayama, M.; Inai, M.; Goto, S.; Kanai, Y.; Watanabe, K.; Yoshida, K.; Furuta, T.; Kan, T.; Suzuki, T. Biochem. Biophys. Res. Commun. 2009, 609–613.

(2) “Stereocontrolled total synthesis of (–)-myriocin” Inai, M.; Goto, T.; Furuta, T.; Wakimoto, T.; Kan, T. Tetrahedron: Asymmetry 2008, 19, 2771–2773.

(1) “A Practical Total Synthesis of (+)-Antimycin A9” Nishii, T.; Inai, M.; Kaku, H.; Horikawa, H.; Tsunoda, T. J. Antibiot. 2007, 60, 65–72.


Review
(1) “Ecteinascidins. A Review of the Chemistry, Biology and Clinical Utility of Potent Tetrahydroisoquinoline Antitumor Antibiotics” Le, V.; Inai, M.; Williams, R. M.; Kan T. Nat. Prod. Rep. 2015, 32, 328–347.